Author/Authors :
nejad, m.r. shahid beheshti university, تهران, ايران , sherafat, s.j. shahid beheshti university, تهران, ايران , roshani, m. shahid beheshti university, تهران, ايران , telkabadi, m. golestan hospital, artesh university of medical sciences, ايران , lahmi, f. shahid beheshti university, تهران, ايران , cheraghipour, k. department of parasitology, lorestan veterinary office, ايران , kaboli, a.r. shahid beheshti university, تهران, ايران , alavi-moghaddam, m. shahid beheshti university, تهران, ايران
Abstract :
Aim: We investigated whether the level of IL8 was different in patients with chronic and acute Toxoplasma gondii infection during the pregnancy compared with control group. Background: It is well established that T. gondii infection induces a strong cell-mediated immune response. Patients and methods: ELISA was used to determine the level of IL8 in sera of 568 pregnant women. Patients were divided into three groups according to a T. gondii serology. The first group included 202 women with positive IgG titres, the second group was 66 women with IgM and negative IgG T. gondii serology; and the third group comprised the sera of 300 healthy pregnant women with negative T. gondii serology and served as controls. Results: The level of IL8 in group I was within normal range similar to control group. However, the level of IL8 was increased in those pregnant patients with positive IgM T. gondii serology. Conclusion: The serum levels of pro-inflammatory cytokines such as IL8 seem to be increased in patients with serological evidence of acute T. gondii infection. © 2011 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
