Author/Authors :
Rahimzadeh, Nahid tehran university of medical sciences tums - Pediatric Transplantation and Dialysis Research Center, تهران, ايران , Otukesh, Hasan tehran university of medical sciences tums - Pediatric Transplantation and Dialysis Research Center, تهران, ايران , Hoseini, Rozita tehran university of medical sciences tums - Pediatric Transplantation and Dialysis Research Center, تهران, ايران , Shadani, Shiva tehran university of medical sciences tums - Pediatric Transplantation and Dialysis Research Center, تهران, ايران , Hooman, Nakysa tehran university of medical sciences tums - Pediatric Transplantation and Dialysis Research Center, تهران, ايران
Abstract :
Introduction. Procalcitonin is a reliable and specific marker of bacterial infections such as urinary tract infection. Some authors suggest measurement of serum procalcitonin as a predictor of vesicoureteral reflux (VUR). We investigated this association in children admitted because of acute pyelonephritis. Materials and Methods. Forty-eight children with the first febrile urinary tract infection were included. Twelve patients had low-grade VUR, 9 patients had high-grade VUR, and 27 patients did not have any VUR in their imaging assessment. Results. There was a significant association between high-grade VUR and higher levels of procalcitonin (P = .04). The sensitivity of a procalcitonin level of 0.31 ng/mL or greater was 90% and the specificity was 32% for diagnosis of high-grade VUR. Conclusions. We concluded that serum procalcitonin concentration is a sensitive and promising predictor of high-grade VUR.
