Author/Authors :
faidi, f. umm al-qura university - center for scientific research (qcsr), Saudi Arabia , faidi, f. camur (centre d assistance médicale urgente et de réanimation) - laboratory of toxicology and environment (lr12sp07), Tunis, Tunisia , faidi, f. tunisia occupational safety and health institute, Tunis, Tunisia , hammami, s. el manar university - faculty of sciences - department of chemistry, Tunis, Tunisia , hammami, s. umm al-qura university - center for scientific research (qcsr), Saudi Arabia , sallem, f. el manar university - faculty of sciences - department of chemistry, Tunis, Tunisia , ben khalifa, e. el manar university - faculty of sciences - department of chemistry, Tunis, Tunisia , ben khalifa, e. tunisia occupational safety and health institute, Tunis, Tunisia , chakroun, r. tunisia occupational safety and health institute, Tunis, Tunisia , chakroun, r. king abdulaziz university - faculty of meteorology, environment and arid land agriculture - department of environmental sciences, Jedda, Saudi Arabia , hedhili, a. camur (centre d assistance médicale urgente et de réanimation) - laboratory of research toxicology-environment(lr12sp07), Tunis, Tunisia
Abstract :
Selective ion monitoring gas chromatography-mass spectrometry (SIM GC-MS) detection method using Chemometric and optimization approach was improved for the determination of eight glycol ethers (GEs): Ethylene glycol methyl ether (EGME), Ethylene glycol ethyl ether (EGEE), Ethylene glycol n-butyl ether (EGBE), 2-Propylene glycol 1-methyl ether (2PG1ME), Ethylene glycol methyl ether acetate (EGMEA), Ethylene glycol ethyl ether acetate (EGEEA), Ethylene glycol n-butyl ether acetate(EGBEA) and 2-Propylene glycol 1- methyl ether acetate (2PG1MEA) in workplace air. A complete separation and faster analysis of these GEs has been achieved in less than 11 min of running time. The DB-624 capillary column used was highly stable with a maximum operating temperature of 360°C, presenting an extremely low bleeding at the working oven temperature program. The application of t-test and analysis of variance (ANOVA) to study GEs extraction from NIOSH charcoal tube with dichloromethane, carbon disulfide and dichloromethane / methanol, indicated that better recoveries were obtained with 5% methanol in dichloromethane. Response surface methodology (RSM) and Doehlert experimental design were used to evaluate the impact of the solvent volume, the desorption time and theirinteraction on the recovery of GEs. A significant impact of the desorption time was shown for all GEs. As for solvent volume, a significant impact was only mentioned for EGME, EGEE, EGBE and 2PG1ME. The optimal conditions of solvent volume and desorption time were found to be 2mL and 20min. The obtained recoveries of GEs ranged from 97.2% to 99.5%. The precision of the method, as indicated by the relative standard deviations (RSDs), was within the range from 2.5% to 5.1%. The detection limits of ethylene glycol ether derivatives (EGEs) ranged between 0.06 and 1.73mg m^-3. The method was applied to study the storage conditions of workplace air samples.
Keywords :
Glycol ethers , Charcoal tube , desorption , Gas chromatographymassspectrometry , Chemometric
