Antioxidant and Antimicrobial Activity of Some Transition Metal Complexes with Non-natural Amino Acids Used As Ligand

In this study, our main objective was to evaluate the antioxidant and antimicrobial activity of three new metal complexes of Cu(II), Fe(III), Co(II), with non-natural amino acids containing quaternary ammonium salts moieties used as ligand derived from 2- (diethylamino)ethylmethacylate (DEAEMA). All the compounds tested in this work were evaluated for their in vitro antimicrobial activities. And for their possible in-vitro antioxidant activity through free radical scavenging activity using DPPH (1,1-diphenyl- 2-picryl-hydrazyl) method. All the compounds showed DPPH radical scavenging activity, where compound CuL_2 and FeL_3 was the best radical scavenger by IC_50 of 0.84 and 1.43 mg/ml, respectively. The results of antimicrobial activity showed that the tested compounds exhibited good to moderate activity against the tested bacterial and fungal strains.