Title of article :
Identification of homogeneously staining regions in leukemia patients
Author/Authors :
Heydarian Moghadam, Mohammad shahid beheshti university of medical sciences - School of Medical Rehabilitation, تهران, ايران , Movafagh, Abolfazl shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Omrani, MirDavood shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Ghanati, Kiandokht shahid beheshti university of medical sciences - Research Department, تهران, ايران , Hashemi, Mehrdad islamic azad university - Department of Genetics, ايران , Poursafavi, Farhikhteh shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Darvish, Hossein shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Zare Abdolahi, Davood shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Gholami, Milad shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Heidari Rostamy, Mohammad Reza shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Safari, Shamsi shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , HaghNejad, Leyla shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Darehgazani, Reyhaneh shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Safavi Naeini, Niloofar shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Ghandehari Motlagh, Mehdi tehran university of medical sciences tums - School of Dentistry - Department of Pediatric Dentistry, تهران, ايران , Amani, Davar shahid beheshti university of medical sciences - School of Medicine - Department of Immunology, تهران, ايران
From page :
363
To page :
365
Abstract :
Homogeneously staining regions (HSR) or double minute chromosomes (dmin) are autonomously replicating extra‑chromosomal elements that are frequently associated with gene amplification in a variety of cancers. The diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. This study report two cases, one with Acute Myeloblastic Leukemia without maturation (AML-M1), aged 23‑year‑old female, and the other with chronic myelogenous leukemia (CML)‑blast crisis, a 28‑year‑old female associated with double minute chromosomes. Most cases of acute myeloid leukemia with dmin in the literature (including our cases) have been diagnosed as having acute myeloid leukemia.
Keywords :
AML , cancer , chronic myelogenous leukemia , homogeneously staining regions dmin , HSRs , Iran , incidence , leukemia , new case
Journal title :
Journal of Research in Medical Sciences
Journal title :
Journal of Research in Medical Sciences
Record number :
2584707
Link To Document :
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