Adiponectin gene polymorphisms and susceptibility to atherosclerosis: A meta‑analysis

Previous studies have inspected the associations between Adiponectin (ADIPOQ) 276G/T polymorphisms and atherosclerosis, but the results are inconclusive. The aim of this study was to explore the relationship between polymorphism +276 G T (rs1501299) in ADIPOQ and atherosclerosis. A widespread search was directed to identify all studies on the association of ADIPOQ 276G/T polymorphism with atherosclerosis risk. The fixed effect pooled measures according to odds ratio (OR) and 95% confidence interval (CI) were calculated in the meta‑analysis. Heterogeneity among studies was evaluated using Q test and the I². Publication bias was estimated using modified Egger’s linear regression test and Fuunel plot. Nine studies regarding the associations between the ADIPOQ 276G/T polymorphism and atherosclerosis risk were enrolled in this meta‑analysis, including 1959 cases and 3739 controls. The 276G/T polymorphism was not significantly associated with atherosclerosis, yielding pooled ORs of 0.925 (95% CI: 0.728‑1.178) and 0.921 (95% CI: 0.804‑1.054), for TT versus GG, and TG versus GG, respectively. Significant between‑study heterogeneity was not found in our meta‑analysis. Furthermore there was no evidence of publication bias in the meta‑analysis. The present meta‑analysis showed that there is no association between ADIPOQ 276G/T polymorphism and atherosclerosis. High quality studies are still needed to add for more investigation of the association between ADIPOQ 276G/T polymorphisms and atherosclerosis.