1st Order Derivative Spectrophotometry Determination of Sertraline in Pharmaceutical Tablets by P-Chloranilic Acid

Rapid, accurate and sensitive method has been developed and validated for the determination of Sertraline in pharmaceutical tablets; the present method is based on First Order derivative spectrophotometry of the colored product which was formed by charge transfer complexation of sertraline (n-donor) with п-acceptor chloranilic acid. First derivative spectrophotometry has been evaluated by measuring of the derivative signal at 475.72 nm – 588.40 nm (peak to peak amplitude). Calibration graph was established for 5-100 μg.mL-1 of sertraline with main percentage recoveries. The proposed method was applied successfully to the determination of sertraline in pharmaceutical tablet with good accuracy and precision.