Author/Authors :
Ali, Hapipah M. university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Abdul Halim, Siti Nadiah university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Subramaniam, Puvaneswary university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Zain, S.M. university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Basirun, W. Jefri university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Ismail, Endom 3National University of Malaysia, Malaysia , Abdullah, Noorlidah university of malaya - Faculty of Science - Institute of Biological Science, Malaysia , Teoh, H.L. university of malaya - Faculty of Science - Institute of Biological Science, Malaysia
Abstract :
The new zinc(II) complexes have been prepared in ethanol by condensation of 2-hydroxyacetophenone with either benzhydrazide or 3-methoxybenzhydrazide and zinc acetate in the presence of triethylamine. The IR, 1 H, 13C NMR and UV-visible data show coordination of hydrazone ligands to the metal centers and the spectroscopic data augur well with the x-ray structures which had been publi shed earlier. The Schiff bases and their complexes were screened for antimicrobial, cytotoxic and antioxidant activities. The anti-microbial activities of the ligands and complexes were evaluated by using plate diffusion method against some gram-positive bacteria, gram-negative bacteria and two fungi . There was growth inhibition exhibited by ligands and zinc(II) complexes against tested bacteria and fungi. The Schiff base , Hzhapbh was cytotoxic with IC50 10.0 µgml^-1 against the MCF-7 (human breast cancer cells) whil e both zinc(II) dimer complexes were strongly cytotoxic with IC50 values of 4.5 µgml^-1. The Schiff bases and zinc(II) complexes showed higher antioxidant activity than quercetin or vitamin E and is comparable with butylated hydroxytoluene (BHT), a commercially used synthetic antioxidant.
Keywords :
Hydrazone Schiff bases , zinc(Il ) complexes , cytotoxicity , antioxidant and antimicrobial activities
