Title of article :
In vivo Antineoplastic Activities of Benzoin Thiosemicarbazone and Para-Anisaldehyde Semicarbazone against Ehrlich Ascites Carcinoma Cells
Author/Authors :
Ali, Mohsin University of Rajshahi - Department of Applied Chemistry and Chemical Engineering, Bangladesh , Jesmin, Mele University of Rajshahi - Department of Applied Chemistry and Chemical Engineering, Bangladesh , Mondal, Sarozit University of Rajshahi - Department of Applied Chemistry and Chemical Engineering, Bangladesh , Abu Rashed University of Rajshahi - Department of Applied Chemistry and Chemical Engineering, Bangladesh , Khairul Islam University of Rajshahi - Department of Applied Chemistry and Chemical Engineering, Bangladesh
Abstract :
Two Schiff bases, namely benzoin thiosemicarbazone (BTSC) and para-anisaldehyde semicarbazone (PAS), were synthesized and characterized. The antineoplastic activities of these Schiff bases were studied against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice by monitoring tumor cell growth inhibition, tumor weight measurement, survival time of tumor-bearing mice, bioassay of these compounds, and counting the total number of peritoneal cells as well as macrophages. Hematological parameters were also studied. It was found that these compounds significantly reduced tumor cell growth rate, decreased tumor weight, and increased life span of EAC-bearing mice. These test compounds restored the hematological parameters of EAC-bearing mice to normal. These compounds also enhanced the number of macrophages in normal mice. The results obtained were compared with those obtained with the standard drug bleomycin.
Keywords :
Antineoplastic activity , benzoin thiosemicarbazone , EAC cells , para , anisaldehyde semicarbazone
Journal title :
Medical Journal of Islamic World Academy of Sciences
Journal title :
Medical Journal of Islamic World Academy of Sciences
