Author/Authors :
Nacar, Alper Bugra Mustafa Kemal University - School of Medicine, Antakya State Hospital - Department of Cardiology, Turkey , Erayman, Ali Mustafa Kemal University - School of Medicine, Antakya State Hospital - Department of Cardiology, Turkey , Kurt, Mustafa Mustafa Kemal University - School of Medicine, Antakya State Hospital - Department of Cardiology, Turkey , Buyukkaya, Eyup Mustafa Kemal University - School of Medicine, Antakya State Hospital - Department of Cardiology, Turkey , Karakaş, Mehmet Fatih Mustafa Kemal University - School of Medicine, Antakya State Hospital - Department of Cardiology, Turkey , Akcay, Adnan Burak Mustafa Kemal University - School of Medicine, Antakya State Hospital - Department of Cardiology, Turkey , Buyukkaya, Sule Mustafa Kemal University - Antakya State Hospital, School of Medicine - Department of Cardiology, Turkey , Sen, Nihat Mustafa Kemal University - School of Medicine, Antakya State Hospital - Department of Cardiology, Turkey
Abstract :
Objectives: To investigate the relationship between neutrophil/ lymphocyte ratio (NLR) and coronary collateral circulation (CCC) in patients with coronary chronic total occlusion. Subjects and Methods: Our study population consisted of 275 consecutive patients with chronic total occlusion. One hundred and thirty-eight patients with chronic total occlusion were included in the study. They were classified into 2 groups as follows: impaired CCC (group 1: Rentrop grades 0–1) and good CCC (group 2: Rentrop grades 2–3). The NLR was calculated from the complete blood count. Results: The NLR values of the patients with impaired CCC (4.5 ± 0.7) were significantly higher than of those with good CCC (2.7 ± 0.6, p 0.001). In the multivariate logistic regression test, NLR (OR 33.36, 95% CI 8.189–135.7, p 0.001), highsensitivity C-reactive protein (hs-CRP; OR 2.152, 95% CI 1.226–3.777, p = 0.008), estimated glomerular filtration rate (OR 1.167, 95% CI 1.049–1.298, p = 0.004) and systolic blood pressure (OR 1.068, 95% CI 1.009–1.1310, p = 0.025) were independent predictors of impaired CCC. The NLR value 3.55 yielded an area under the curve value of 0.957 (95% CI 0.921–0.992, p 0.001) and demonstrated a sensitivity of 95% and a specificity of 90% for the prediction of CCC. A moderate correlation between NLR and hs-CRP was observed (r = 0.443; p 0.001). Conclusion: Our findings reveal that NLR correlates with the impaired development of coronary collaterals.
