Author/Authors :
Ellepola, Arjuna N.B. Kuwait University - Faculty of Dentistry, Faculty of Medicine, Health Sciences Center - Department of Bioclinical, Department of Diagnostics and Restorative Sciences, Kuwait , Joseph, Bobby K. Kuwait University - Faculty of Dentistry, Faculty of Medicine, Health Sciences Center - Department of Bioclinical, Department of Diagnostics and Restorative Sciences, Kuwait , Altarakemah, Yacoub Kuwait University - Faculty of Dentistry, Faculty of Medicine - Department of Bioclinical, Department of Diagnostics and Restorative Sciences, Kuwait , Samaranayake, Lakshman P. University of Queensland - School of Dentistry - Oral Microbiomics and Infection, Australia , Anil, Sukumaran King Saud University - College of Dentistry - Department of Periodontics and Community Dentistry, Saudi Arabia , Hashem, Mohamed King Saud University - College of Applied Medical Sciences - Dental Health Department, Saudi Arabia , Khan, Zia U. Kuwait University - Faculty of Medicine, Health Sciences Center, Faculty of Dentistry - Department of Microbiology, Department of Diagnostics and Restorative Sciences, Kuwait
Abstract :
Objectives: We aimed to investigate the effect of brief exposure to sub-cidal concentrations of nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate on the adhesion of oral Candida dubliniensis isolates to the surface of acrylic dentures. Methods: After determining the minimum inhibitory concentration of each drug, 20 oral isolates of C. dubliniensis were exposed to sub-cidal concentrations of the drugs for 1 h. The drugs were then removed by dilution, and the adhesion of the isolates to denture acrylic 74.27, 57.31, 44.57 and 56.53% (p 0.001 for all drugs), respectively. Conclusions: Brief exposure to sub-cidal concentrations of anti-mycotics suppressed the adhesion of C. dubliniensis oral isolates to acrylic denture surfaces.strips was assessed by an in vitro adhesion assay. Results:Compared to the controls, exposure to nystatin, amphotericinB, ketoconazole, fluconazole and chlorhexidine gluconatesuppressed the ability of C. dubliniensis isolates to adhereto acrylic denture surfaces with a reduction of 74.68,
