The Effect of Starch VS Crystalloid Administration of Cardiopulmonary Bypass Prime Solution on Tissue and Organ Perfusion and Coagulation Status

Background: We evaluated the effects of tissue and organ perfusion and Coagulation status and hemorrhage in open heart surgery with the use of Cardiopulmonary Bypass with Starch (colloid) or crystalloid (Lactated ringer’s) as prime solution. Methods: In this prospective randomized-controlled trial study, 40 patients undergoing on-pump open heart surgery were randomly assigned to receive either colloid (Starch) or crystalloid (Lactated ringer’s) as prime solution, for initiation of cardiopulmonary bypass machine procedure. Tissue and organ perfusion markers and Coagulation test including lactate, and renal function tests and PTT , INR were measured sequentially Results: Although the differences in PTT/INR/ Cr/ Plt Count between two groups was not significant but Bleeding and drainage in 6 and 24 interval after operation was higher in Starch group and also Urine Out Pout during operation in Ringer Lactate group was higher than Starch group. Conclusion: In Tissue and Organ perfusion variable there was no Statistical differences but Priming with Starch have tendency to excessive Bleeding and Coagulopathy.