Relationship between 24-hour mean pulse pressure and the cardiac function in the elderly with isolated systolic hypertension

Objective: To investigate the effect of mean pulse pressure during 24 hours on cardiac function in the elderly with isolated systolic hypertension.Methodology: One hundred seventy two elderly patients with isolated systolic hypertension were enrolled to determine mean pulse pressure by monitoring 24-hour ambulatory blood pressure and to analyze the cardiac function by nuclide cardiac blood pool imaging.Results: Twenty four hours mean pulse pressure negatively correlated with left ventricular ejection fraction (LVEF) ( r = - 0.46, P 0.01 ), and also with peak filling rate (RFR) ( r = - 0.41, P 0.05). The greater the mean pulse pressure, the worse the cardiac function (P 0.01).Conclusion: The 24-hours mean pulse pressure was an important factor predicting risk for cardiac disfunction in the elderly with isolated systolic hypertension