Kinetics of HLA antibodies: A Titanic effort is required

Recently, Jackman et al., have published a very interesting paper entitled ‘Low-level HLA antibodies do not predict platelet transfusion failure in TRAP study participants.1 The authors have profoundly explained the possible mechanisms that might be responsible for the platelet refractoriness in the 19% of recipients who had no detectable human leukocyte antigens (HLA) antibodies using the lymphocytoxocity assay (LCA), but were at low levels detected using the sensitive bead-based multiplexing assay.