Title of article :
Studying the Effect of a Maltitol Solution on the Stability of Water Soluble Vitamins
Author/Authors :
Sakeer, Khalil The Syrian International Private University for Science and Technology - Faculty of Pharmacy - Department of Pharmaceutics and Pharmaceutical Technology, Syria , Al-Zein, Hind Damascus University - Faculty of Pharmacy - Department of Pharmaceutics and Pharmaceutical Technology, Syria
Abstract :
The stability of vitamins in a liquid dosage form is still considered a challenge to pharmacists to obtain a stableformula. The objective of this study was to formulate multi-water soluble vitamin oral solutions, study thestability of this formulation at accelerated conditions 40 ± 2 oC / 75% ± 5% RH for two months and investigatethe effect of the pH and the percent of a maltitol solution on the stability of the vitamins. Results showed thatusing a 30% maltitol solution gave a pronounced improvement in the stability of vitamins compared with asorbitol solution, and the pH had a critical role on the stability of vitamins so the vitamins had an optimumstability at pH between 3.5 – 4
Keywords :
water soluble vitamins , maltitol solution , accelerated condition , sorbitol solution
Journal title :
Jordan Journal of Pharmaceutical Sciences
Journal title :
Jordan Journal of Pharmaceutical Sciences
