Title of article :
Mean platelet volume can predict cerebrovascular events in patients with Sickle Cell Anemia
Author/Authors :
Celik, Tanju Mustafa Kemal University - School of Medicine - Department of Pediatrics, Turkey , Unal, Sule Antakya State Hospital - Pediatric Hematology Clinic, Turkey , Ekinci, Ozalp Ozalp Ekinci Child and Adolescent Psychiatry Clinic, Turkey , Ozer, Cahit Mustafa Kemal University - School of Medicine - Department of Pediatrics, Turkey , Ilhan, Gul Antakya State Hospital - Division of Internal Medicine Hematology Oncology, Turkey , Oktay, Gonul Antakya State Hospital - Blood Disease Center, Turkey , Arica, Vefik Mustafa Kemal University - School of Medicine - Department of Paediatric, Turkey
From page :
203
To page :
208
Abstract :
Objective: The purpose of this study was to determine the impact of mean platelet volume (MPV) on the frequency and severity of vaso-occlusive and cerebrovascular events in patients with sickle cell anemia (SCA). Methods: The 238 cases diagnosed with SCA were evaluated retrospectively with respect to the occurrence of painful crisis for the previous year. The incidence, severity and type of the vaso-occlusive crises of the patients with SCA between March 2010 and March 2011 were recorded. The last MPV values in patients who were free of erythrocyte transfusion for the last three months and who had no current vaso-occlusive crises were evaluated. All the patients were grouped according to the frequency of the crises for the previous year preceding the data collection. Group 1: 1 to 3 crises, Group 2: 4 to 5 and Group 3: 6 or more crises annually. Results: In accordance with the results obtained during the evaluation of the cases diagnosed with sicklecell anemia, MPV value was found to be significantly higher in patients with cerebrovascular events. Also MPV values increased with increasing incidence of the crises (r=0.297) (p=0.001). Conclusion: One of the contributing factors for this clinical heterogeneity may be related to the MPV values in patients with sickle cell anemia. The higher MPV values may be an early predictor of future cerebrovascular events in patients with sickle cell anemia and may require close follow-up and additional measures.
Keywords :
Platelets , Sickle cell anemia , Thrombosis
Journal title :
Pakistan Journal of Medical Sciences
Journal title :
Pakistan Journal of Medical Sciences
Record number :
2587375
Link To Document :
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