Association of Tumor Necrosis Factor Receptor Type 2 Gene Polymorphism with Severe Chronic Periodontitis

Background and aims. The aim of the present study was to evaluate the association between TNFR2 (+587T/G) gene polymorphism and chronic periodontitis (CP). Materials and methods. One hundred and seventy-four non-smoking patients (35-72 years of age) with chronic periodontitis were selected according to established criteria and divided into three groups according to their probing pocket depth (PPD), clinical attachment level (CAL), and alveolar bone loss (ABL). Single nucleotide polymorphism at position +587 (T/G) in the TNFR2 gene was detected by a polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method. Results. The distribution of genotypes for TNFR2 polymorphism at position +587 was not significantly different between moderate and severe chronic periodontitis patients compared with controls (P=0.33). In addition, the frequency of the +587 allele was not associated with the number of teeth (P=0.58), mean PPD (P=0.9), mean CAL (P=0.94), mean ABL (P=0.99) and bleeding on probing (BOP) (P=0.07) in the patients studied. Conclusion. This study suggests that there is no correlation between genotype and severity of chronic periodontitis.