Comparison between Allopurinol and Febuxostat in management of gout patients - a prospective study

Aim:To assesses the efficacy of a relatively new drug-Febuxostat in management of gout and its compari- son with allopurinol. Method: A comparative study of both Allopurinol and Febuxostat was done on 100 patients of gout. Both were studied for efficacy. side effects and for gout flare up. Results: Primary effica- cy end point (baseline values) - a serum urate concentration of less than 6.0mg per deciliter at the last three measurements was reached by 54 %( 27/50) of group A patients taking 80mgs of febuxostat and 25 %( 12/50) of group B patients taking allopurinol 300mgs per day (P 0.001) Secondary ef ficacy end point(fol- low up values)- At first visit (after 2 weeks of onset of study), the proportions of subjects with serum urate concentration of less than 6.0mg/dl was significantly higher in the group A receiving febuxostat than the group B receiving allopurinol(P 0.001)[T ableno-1]. Conclusion: Febuxostat, at a daily dose was more effective than of side effects and gout flare up were similar in both groups.