Author/Authors :
Honar, N. shiraz university of medical sciences - Nemazee Hospital - Gastroenterohepatology Research Center, ايران , Imanieh, M. H. shiraz university of medical sciences - Nemazee Hospital - Gastroenterohepatology Research Center, ايران , Imanieh, M. H. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, ايران , Haghighat, M. shiraz university of medical sciences - Nemazee Hospital - Gastroenterohepatology Research Center, ايران , Dehghani, S. M. shiraz university of medical sciences - Nemazee Hospital - Gastroenterohepatology Research Center, ايران , Dehghani, S. M. shiraz university of medical sciences - Nemazee Hospital - Clinical Microbiology Research Center, ايران , Zahmatkeshan, M. shiraz university of medical sciences - Nemazee Hospital - Gastroenterohepatology Research Center, ايران , Geramizadeh, B. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, ايران , Badiee, P. shiraz university of medical sciences - Nemazee Hospital - Clinical Microbiology Research Center, ايران , Nikeghbalian, S. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, ايران , Kazemi, K. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, ايران , Bahador, A. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, ايران , Salahi, H. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, ايران , Malek-Hosseini, S. A. shiraz university of medical sciences - Nemazee Hospital - Shiraz Transplant Research Center, ايران
Abstract :
Background: Liver transplantation (LT) is the standard treatment of end-stage liver diseases (ESLD). Invasive fungal infection is one of the important causes of morbidity and mortality after transplantation.Objective: To determine the incidence of late-onset (after 6 months of LT) Candida infection in recipients.Methods: A retrospective study was conducted to evaluate 50 pediatric patients after LT for 8 years at theLT Unit of Nemazee Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. We followed the patients until 6 months post-LT for episodes of Candida infection proven by culture.Results: One recipient (2%) developed late-onset esophageal candidiasis with improvement after intravenous amphotricin therapy but finally expired with a diagnosis of post-transplant lymphoproliferative disorder (PTLD).Conclusions: The incidence of late-onset Candida infection is not significant in pediatric liver recipient, but it still remains a significant problem. Control of Candida colonization would reduce the risk of invasive fungal infections and possibly more fatal complications.
Keywords :
Children , Liver transplantation , Late , onset Candida infection
