LETTER: Familial Mediterranean Fever E148Q Mutation, Episodic Fever and Kidney Allograft Dysfunction

Familial Mediterranean fever (FMF) is a recessively inherited disease associated with mutations in the FMF gene (MEFV), which encodes the pyrin protein. AA amyloidosis is the most devastating complication of FMF. Nonamyloid renal lesions also have been reported including vasculitis, focal diffuse glomerulonephritis, and immunoglobulin A nephropathy. M694V is the most common mutation of MEFV gene, but E148Q pyrin mutation is also common in some regions.1