Author/Authors :
haque, z.s.m. ad-din medical college hospital, Bangladesh , jahan, n. ad-din medical college hospital - department of neonatology, Bangladesh , raha, b.k. ad-din medical college hospital, Bangladesh , hasan, m. ad-din medical college hospital, Bangladesh , begum, m. ad-din medical college hospital, Bangladesh , rob, a.w.s. ad-din medical college hospital, Bangladesh , yasmin, s. ad-din medical college hospital, Bangladesh , hasnat, s.k.a. ad-din medical college hospital, Bangladesh , farhana, t. ad-din medical college hospital, Bangladesh
Abstract :
Summary: We report the case of a newborn with Down s syndrome associated with transient acute myeloid leukemia (AML). The leukemic presentation resolved spontaneously without treatment just 4 weeks after birth. A 2 days old newborn presented with respiratory distress, lethargy, poor suck and mild hepatosplenomegaly with features of Down s syndrome. Total white cell count was 144,000/cmm with blasts 92%. Other Septic work up was negative. Peripheral blood smear revealed hyper leukocytosis and presence of blast cells. Flow cytometric analysis revealed acute myeloid leukemia. The peripheral blast cells persisted for 4 weeks, after which the hemogram and the differential WBC count returned to normal and a final diagnosis of transient acute myeloid leukemia was made. Only few cases of congenital leukemia with Down s syndrome have been reported in the literature. In Down s syndrome, AML whether transient or not, generally shows cytogenetic and molecular aspects that differ from those of adult acute leukemias.
