Short Communication: Activation of Hailey-Hailey disease by herpes simplex infection in a patient with concomitant two different autoimmune diseases

Sir, our case 61-year-old female was admitted to our dermatology clinic because of severe erythema and pain in her groin. Skin biopsy from her groin and subjected histopathologic examination revealed Hailey-Hailey disease three years ago. She was treated by our dermatolgy clinic for three years. She had also alopecia universalis for nearly 50 years and Hashimato thyroiditis for three years. Patient systemic examination was normal. On dermatologic examination, there were sharply demarcated flaccid vesicles, erosions, fissure and crusting lesions in groin (Figure 1), axilla, submammarian area. She had also alopecia universalis and asymptomatic, longitudinal white bands in the fingernails. Fasting blood glucose, sedimentation, liver function tests, renal function tests in laboratory investigations were within normal limits. Thyroid autoantibody that anti T ( 500 U/mL), anti M ( 1300 U/mL), free T3(1,83 pg/mL) levels were higher than normal. Thyroid ultrasound was consistent with Hashimoto thyroiditis. Herpes simplex type I and type II IgM were negative and type I and II IgG antibody were negative, positive, respectively.