Title of article
Efficacy and safety of simvastatin in chronic plaque psoriasis
Author/Authors
Aslam, Shazia King Edward Medical University - Mayo Hospital - Department of Dermatology, Unit II, Pakistan , Khurshid, Khawar King Edward Medical College - Mayo Hospital - Department of Dermatology, Unit II, Pakistan , Asad, Faria King Edward Medical College - Mayo Hospital - Department of Dermatology Unit II, Pakistan , Rani, Zahida Mayo Hospital - King Edward Medical College - Dermatology Department, Unit I, Pakistan , Pal, Sabrina Suhail King Edward Medical University - Mayo Hospital - Department of Dermatology Unit II, Pakistan
From page
310
To page
314
Abstract
Objective: To determine the efficacy and safety of simvastatin in chronic plaque psoriasis. Patients and methods: Sixty patients of either sex, aged between 18 and 70 years were included in the study. Efficacy was determined by percentage reduction in psoriasis area and severity index (PASI) score from baseline. Safety of simvastatin was evaluated by measuring serum alanine aminotransferase (ALT), creatinine phosphokinase (CPK) and bilirubin at baseline, 4th, 8th and 12th week. The data were analyzed for variables like age, sex and percentage reduction in PASI score. Results: There was 50% reduction in PASI score in 20% patients. Out of these, 8 patients had moderate plaque psoriasis and 4 patients had severe psoriasis. In remaining 80% cases simvastatin did not prove to be efficacious. The drug was safe and well-tolerated. Conclusion: Simvastatin can be affective in patients with moderate disease as compared to cases with severe plaque psoriasis. The drug was safe and well-tolerated.
Keywords
Psoriasis , simvastatin , efficacy , safety.
Journal title
Journal of Pakistan Association of Dermatologists
Journal title
Journal of Pakistan Association of Dermatologists
Record number
2590594
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