The Influence of Brucella Abortus Strain RB51 Vaccine Which is Given to the Mice (Mus musculus) and Infected by Local Isolat Brucella Suis for the Figures of Hepatic Fibrosis of the Mice (Mus musculus)

Brucellosis in hog is caused by a bactery named Brucella Suis. Vaccine is used as a prevention and elimination act for Brucellosis. However, Brucellosis vaccine is not yet available, instead Brucella abortus strain RB51 is used as a vaccine for cattles. On the other hand, the used of RB51 vaccine is still a controversy since there are various result on the related research that have been done. This study was designed to analyze the changes in histopathologic figures of hepatic mice that had been vaccinated against Brucella abortus strain RB51 and infected by Brucella suis. This study used samples of 18 males (Mus musculus) mice aged 8 weeks which weight about 20-30 g and divided into 3 treatment groups, P0 +, P0-, and P. Degree of liver damage as a result of treatment performed on hepatic scores using modification method Knodell (2007) who got the presentation of the scoring result from each treatment. The results of this study shows that the Brucella abortus strain RB51 vaccine did not decrease the number of hepatic necrosis cells of mice (Mus musculus) that had been infected by Brucella suis and Brucella abortus strain RB51 vaccine did not decrease the occurrence of hepatic fibrosis of mice (Mus musculus) that have been infected by Brucella suis. Brucella Abortus strain RB51 vaccine that was given to the mice which had been infected by Local Isofat Brucella suis did not cause any significant changes of the mice histopathological figures of hepatic.