Title of article :
In Vitro Susceptibility of typhoidal Salmonellae against newer antimicrobial agents: A search for alternate treatment options
Author/Authors :
Qaiser, Saba Aga Khan University Hospital - Department of Pathology and Microbiology, Pakistan , Irfan, Seema Aga Khan University Hospital - Department of Pathology and Microbiology, Pakistan , Khan, Erum Aga Khan University Hospital - Department of Pathology and Microbiology, Pakistan , Ahsan, Tanwir Aga Khan University Hospital - Department of Pathology and Microbiology, Pakistan , Zafar, Afia Aga Khan University Hospital - Department of Pathology and Microbiology, Pakistan
Abstract :
Objectives: To determine the minimum inhibitory concentrations (MICs) of ceftriaxone, azithromycin, pefloxacin, cefipime and imipenem for Salmonella Typhi (S. Typhi) and Paratyphi.Methods: One hundred and fifty four isolates of Salmonella Typhi and S. Paratyphi A, B and C growing in blood culture were selected. MICs of ceftriaxone, azithromycin, pefloxacin, cefipime and imipenem were performed by agar dilution method as recommended by clinical laboratory standard institutes.Results: MIC90 of azithromycin and pefloxacin was 8 8g/ ml, cefipime was 0.06 8g/ ml and imipenem was 0.58g/ml. None of the strains were found to be resistant to ceftriaxone but 3 isolates showed higher MIC value of 28g/ml.Conclusion: Azithromycin appears a suitable alternate for the treatment of typhoid in the community. Imipenem and cefipime are good options in complicated cases to be treated in hospital settings. Pefloxacin cannot be used as MICs are higher. Presence of isolates with higher MIC of ceftriaxone is serious and stresses upon continuous laboratory surveillance to guide clinicians appropriately.
Keywords :
Drug resistance , typhoidal Salmonellae , new options
Journal title :
Journal of the Pakistan Medical Association (Centre) JPMA
Journal title :
Journal of the Pakistan Medical Association (Centre) JPMA
