Different approaches to acute organophosphorus poison treatment

Organophosphorus compounds (OPCs) have a wide variety of applications and are a serious threat for selfpoisoning, unintentional misuse, terrorist attack, occupational hazard and warfare attack. The present standard treatment has been reported to be unsatisfactory. Many novel approachesare being used and tested for acute organophosphorus (OP) poison treatment. The bioscavenger concept captured high attention among the scientific community during the last few decades. Other approaches like alkalinisation of blood plasma/serum and use of weak inhibitors against stronginhibitors, though it showed promising results, did not get such wide attention. The introduction of a novel broadspectrum oxime has also been in focus. In this mini-review, an update of the overview offour different approaches has been discussed. The standard therapy that is atropine+oxime+benzodiazepine along with supportive measures will continue to be the best option with only the replacement of a single oxime to improve its broadspectrum efficacy.