Title of article :
Kennedy Disease Misdiagnosed as Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome: A Case Report
Author/Authors :
Yuan, Min The Second Affiliated Hospital of Nanchang University - Department of Neurology, China , Chen, Weiping The Second Affiliated Hospital of Nanchang University - Department of Neurology, China , Zhou, Huangyan Nanchang University - Basic Medical College - Department of Immunologyand Pathogenic Biology, China , Xiao, Zhilong The Second Affiliated Hospital of Nanchang University - Department of Neurology, China , Wang, Wei The Second Affiliated Hospital of Nanchang University - Department of Neurology, China , Wang, Weidong The Second Affiliated Hospital of Nanchang University - Department of Neurology, China , Yin, Xiaoping The Second Affiliated Hospital of Nanchang University - Department of Neurology, China , Xu, Lijun The Second Affiliated Hospital of Nanchang University - Department of Neurology, China
Abstract :
Objective: The aim of this paper was to report the first case of Kennedy disease misdiagnosed as polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. Clinical Presentation and Intervention: A 58-year-old Chinese man presented with limb numbness, progressive limb proximal weakness, lymph node and thyroid enlargement, edema, pigmentation in the lower limb, and obvious gynecomastia, which was initially diagnosed as POEMS syndrome and was treated with dexamethasone and small doses of cyclophosphamide without any improvement after 6 months. Finally, the patient diagnosis was confirmed as Kennedy disease (KD) by gene analysis. Conclusion: This case suggests that clinicians should pay more attention to the differential diagnosis between KD and POEMS syndrome. Gene analysis was helpful in detecting this rare confusing disease in this patient.
Keywords :
Kennedy disease · POEMS syndrome · Gynecomastia · Gene analysis
Journal title :
Medical Principles and Practice
Journal title :
Medical Principles and Practice
