Title of article
Effects of silver nanoparticle (Ag NP) on oxidative stress biomarkers in rat
Author/Authors
Ranjbar, Akram hamadan university of medical sciences - School of Pharmacy - Department of Toxicology and Pharmacology, ايران , Ataie, Zahra alborz university of medical sciences - School of Medicine - Department of Pharmacology and Physiology, ايران , Khajavi, Farzad bu ali sina university of hamadan - Department of Chemistry, همدان, ايران , Ghasemi, Hassan hamadan university of medical sciences - School of Medicine - Department of Biochemistry, ايران
From page
205
To page
210
Abstract
Objective(s): Nanotechnology and nanoparticles are increasingly recognized for their potential applications in aerospace engineering, nanoelectronics, and environmental remediation, medicine and consumer products. More importantly is the potential for the application of silver nanoparticles (Ag NPs) in the treatment of diseases that require maintenance of circulating drug concentration or targeting of specific cells or organs the aim of this study was to investigate the possible protective role of Ag NP antioxidative biomarkers in rats. Ag NPs are used to investigate the potential risks for the environment and health. Materials and Methods: Rats received Ag NP, 5, 50, 250 and 500 mg/kg/day IP. After two week of treatment, the activity of enzymatic scavengers such as glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant capacity (TAC) of blood samples were measured. Results: Ag NP in 5, 50, 250 and 500 mg/kg reduced activities of CAT, SOD and increased TAC in plasma. Conclusion: In this study, Ag NP with 500mg/kg induced activities of CAT, SOD and decreased TAC. It is concluded that antioxidative properties of Ag NP is dose dependent.
Keywords
Enzyme antioxidant , Oxidative stress , Silver nanoparticle (Ag NP)
Journal title
Nanomedicine Journal
Journal title
Nanomedicine Journal
Record number
2591071
Link To Document