Author/Authors :
Sered, Alexey D. Federal Research Center For Virology and Microbiology, Pokrov, Petushki area, Vladimir region, Russia , Makarov, Vladimir V. Peoples’ Friendship University of Russia (RUDN University), Miklukho, Maklaya, Moscow, Russia , Sachivkin, Nadezhda P. Peoples’ Friendship University of Russia (RUDN University), Miklukho, Maklaya, Moscow, Russia , Strizhakov, Aleksander A. Peoples’ Friendship University of Russia (RUDN University), Miklukho, Maklaya, Moscow, Russia , Gnezdilov, Larisa A. Moscow State Academy of Veterinary Medicine and Biotechnology – MVA Named after K.I. Skryabin, Akademika Skryabina Street, Moscow, Russia , Kuznetsov, Vladimir I. Peoples’ Friendship University of Russia (RUDN University), Miklukho, Maklaya, Moscow, Russia , Sturov, Nikolay V. Peoples’ Friendship University of Russia (RUDN University), Miklukho, Maklaya, Moscow, Russia , Zimin, Vera N. Peoples’ Friendship University of Russia (RUDN University), Miklukho, Maklaya, Moscow, Russia
Abstract :
The Teschen disease (enzootic encephalomyelitis, enterovirus encephalomyelitis in pigs) is a viral disease
in pigs, characterized by the development of non-suppurative encephalomyelitis and the emergence of paralysis. Live
and inactivated vaccines are used to prevent the Teschen disease. The vaccines are prepared from tissues of the central
nervous system of infected pigs or using a cultured viral suspension with the addition of various adjuvants. The inactivated vaccine against the Teschen disease protects 70-80% of vaccinated pigs from subsequent intracerebral infection
with a pathogenic virus. The titer of virus-neutralizing antibodies reaches a maximum (1:64 - 1:1444) two weeks after
the second vaccination. Vaccinated pigs with titer of neutralizing antibodies above than 1:32-1:128 are resistant to
infection enterovirus encephalomyelitis of pigs. If the animal was older than 6 weeks age at the time of vaccination
expressed antibody formation was observed. The disadvantages of inactivated vaccines are the low level and short duration of the formed protective immunity. Therefore, to induce and maintain a high level of humoral immunity people are
forced to resort to multiple vaccinations. Another way to amplify the protectiveness of inactivated vaccines is the use of
immunomodulators for the regulation of immunological reactivity. A wide field of activity remains for the selection of
effective immunomodulators and optimal schemes for their combined use with inactivated vaccines. It seems advisable
to determine the possibilities of using a number of immunostimulants produced by the domestic bioproductivity in the
vaccine prophylaxis of viral diseases of farm.
Keywords :
Teschen disease , Viral disease , Domestic pigs , Immunostimulants , Vaccine prophylaxis , Tissue culture infective dose
