Simultaneous Spectrophotometric Determination of Naproxen and Pantoprazole in Pharmaceutical Dosage Form

Two simple, but accurate, precise, reproducible, without separation and economical procedures for simultaneous estimation of naproxen and pantoprazole in combined capsule dosage form have been developed. One method employs solving of simultaneous equations using 262 nm and 289 nm as two analytical wavelengths for both drugs in methanol. The other method is Q- value analysis based on measurement of absorptivity at 262 nm and at isoabsorptive point 310 nm showing linearity in concentration range of 10.0- 50.0 ìg.ml-1 for naproxen and 8.0- 18.0 ìg.ml-1 for pantoprazole. The method was validated with respect to accuracy, precision, limit of detection and limit of quantitation. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and without need to heat and organic solvent extraction.