Role of Integrin Proteins as Receptors for Foot and Mouth Disease Virus

Foot-and-mouth disease (FMD) is an infectious, highly contagious and acute disease of cloven-hoofed animals. The morbidity after infection may reaches to 100% however mortality in adults is relatively low. For FMDV infection to establish host cell adsorption is required and it depends on the cell surface receptors. This review highlights the critical role of integrin proteins as receptors for FMDV. An effective understanding of virus internalization may open new horizon to study virus pathobiology and for establishment of an effective antivirals.