Pathological Changes of Mycobacterium Tuberculosis and Treatments with Alcoholic Extract of Arachis hypogaea and Ethambutol in Mice

The aim of this study is to demonstrate the histopathological changes of alcoholic extract of Arachis hypogaea and ethambutol in increasing the therapeutic efficacy of anti-tuberculosis in treatment of mice infected with mycobacterium tuberculosis. 30 white Swisrland mice of 6-8 weeks age, weighted 20-25gm were used they were randomly divided into 3 groups which infected with mycobacterium tuberculosis (1x108 cfu) , after one month of infection we treated (2) groups: one of them treated with ethambutol & the other treated with ethambutol + alcoholic extract and third group was contral positive . At 60 day post infection all animals were scarified and samples from different organs (liver, lungs, kidneys, spleen, and intestine) were fixed in 10% neutral buffered formalin for histopathological examination. The result of present study revealed no lesion or mild of internal organs of animal that treated with extract + ethambutol comparing with animal group treated with ethambutol only that showed moderate lesion while infected animal group showed sever pathological lesion characterized by granulomatous lesion in liver and lung also congestion with degenerative changes seen in kidney