Title of article :
Synthesis and characterization of the novel 80S bioactive glass: bioactivity, biocompatibility, cytotoxicity
Author/Authors :
Bakhtiari ، Ameneh Department of Biology - Shahid Chamran University , Cheshmi ، Amir Department of Materials Engineering - Babol Noshirvani University of Technology , Naeimi ، Maryam School of Nursing and Midwifery - Tehran University of Medical Science , Fathabad ، Sobhan Mohammadi Department of Engineering and High-Tech - Iran University of Industries and Mines , Aliasghari ، Maryam Young Researchers and Elite Club - Islamic Azad University, Yadegar-e-Imam Khomeini (RAH) Shahr-e-Rey Branch , Modarresi Chahardehi ، Amir Integrative Medicine Cluster - Advanced Medical and Dental Institute - Universiti Sains Malaysia , Hassani ، Sahar Department of Cellular and Molecular Biology - Facaulty of Advanced Science and Technology - Islamic Azad University, Tehran Medical Sciences Branch , Elhami ، Vahideh Sustainable Process Technology Group - Faculty of Science and Technology - University of Twente
Abstract :
In this research, the 80S bioactive glass with different Ca/P ratios was prepared by the sol-gel route. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Fourier transforms infrared spectroscopy (FTIR) were used to study the apatite structure and shape. According to the results, the 78SiO2–17P2O5–5CaO bioglass showed a higher rate of crystalline hydroxyapatite (HA) on its surface in comparison with the other bioglasses. After 3 days of immersion in the SBF solution, spherical apatite was formed on the 78SiO2–17P2O5–5CaO surface, which demonstrated high bioactivity. A statistically significant promotion in proliferation and differentiation of G292 osteoblastic cells was also observed. Regarding its optimal cell viability and bioactivity, the 78SiO2–17P2O5–5CaO bioactive glass could be offered as a promising candidate for bone tissue applications.
Keywords :
Bioactive glass , 80S , Ca , P ratio , Hydroxyapatite
Journal title :
Journal of Composites and Compounds
Journal title :
Journal of Composites and Compounds
