Title of article
Identification and Bioactivity Studies of Flavonoid Compounds from Macaranga hispida (Blume) Mull.Arg
Author/Authors
Megawati Lembaga Ilmu Pengetahuan Indonesia (LIPI) - Research Center for Chemistry, Indonesia , Saepudin, Endang university of indonesia - Faculty of Mathematics and Natural Sciences - Department of Chemistry, Indonesia , Hanafi, Muhammad Lembaga Ilmu Pengetahuan Indonesia (LIPI) - Research Center for Chemistry, Indonesia , Darmawan, Akhmad Lembaga Ilmu Pengetahuan Indonesia (LIPI) - Research Center for Chemistry, Indonesia , Lotulung, Puspa Dewi N. Lembaga Ilmu Pengetahuan Indonesia (LIPI) - Research Center for Chemistry, Indonesia
From page
96
To page
100
Abstract
Two flavonoid compounds, 5,7,3’,4’-tetrahydroxy-6-geranylflavonol (1) and kaempferol 7-O-β- glucose (2) have been isolated from the leaves of Macaranga hispida (Blume), Mull.Arg. Isolation and purification were conducted by chromatography methods and chemical structure characterization was carried out by spectroscopic methods. The 5,7,3’,4’-tetrahydrxyi-6-geranyl flavonol (1) and kaempferol 7-O-glucose (2) had moderate cytotoxic activity against murine leukemia P-388 cell lines with IC_50 value of 0.22 and 101.5 μg/mL, respectively. The IC_50 for antioxidant activities of (1) and (2) were 2.83 and 13.95 μg/mL, respectively. The LC_50 of (1) and (2) from BSLT were 350 and 1000 μg/mL, respectively.
Keywords
anti cancer murine leukemia P , 388 cell lines , antioxidant activity , BSLT , kaempferol 7 , O , glucose , cytotoxicity , Macaranga hispida (Blume) Mull. Arg , 5 , 7 , 3’ , 4’ , tetrahydroxy , 6 , geranyl flavonol
Journal title
Makara Journal Of Science
Journal title
Makara Journal Of Science
Record number
2594723
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