Cytotoxic Triterpenoid from the Stembark of Chisocheton celebicus (Meliaceae)

Plants belonging to the Chisocheton genus are a rich source of tetracylic triterpenoids with diverse biological activities. Two triterpenoid compounds, dammar-20,24-dien-3-one (1) and 3β-hydroxy-tirucall-7-en (2) were isolated from the stembark of Chisocheton celebicus. The chemical structures of compounds 1 and 2 were identified by spectroscopic data, including IR, NMR (^1H, ^13C, DEPT 135◦, HMQC, HMBC, ^1H-^1H COSY), and MS, and they were compared with previously reported spectral data. Compounds 1 and 2 were evaluated for their cytotoxic effects against P-388 murine leukemia cells. The compounds showed cytotoxicity against P-388 murine leukemia cells, with IC50 values of 30.2 and 4.3 μg/mL, respectively.