Coagulopaty due to Cefoperazone/Sulbactam in a Patient with Chronic Renal Failure: Case Report

Continuous ambulatory peritoneal dialysis is one of renal replacement treatment in patients with end-stage kidney disease. Peritonitis is a serious problem in peritoneal dialysis patients that leads to hospitalisation and increased mortality. In treatment of peritoneal dialysis- associated peritonitis, broad spectrum antibiotics have been used according to potential dominant microorganism. With the extended spectrum and a remarkably safe, third generation cephalosporins are used frequently in clinics. Cefoperazone/sulbactam, which is one of the third generation cephalosporins, causes bleeding because of it induces hypoprothrombinemia. We report that in a patient with peritoneal dialysis, bleeding by inducing hypoprotrombinemia developing during cefoperazone/sulbactam therapy.