The Effects of Flumazenile and Naloxone on Antinociception of Dexmedetomidine

Purpose: The aim of this study was to search the effects of flumazenil and naloxane, which are frequently used in intensive care units for benzodiazepine and opioid antagonism, on dexmedetomidine s antinociceptive effect. Material and Methods: 50 Bulb-C albino mice, weight between 25-35 grams, were used in the study. Mice were randomized in to 5 groups (n=10). Serum physiologic, 200 mg/kg of dexmedetomidine, 1 mg/kg of yohimbine + 200 mg/kg of dexmedetomidine, 1 mg/kg of flumazenil + 200 mg/kg of dexmedetomidine or 2 mg/kg of naloxone + 200 mg/kg ofdexmedetomidine were applied to each mouse in every group. Although no significant analgesiceffect was observed in 20., 40., 60., and 80. minutes in control group and yohimbine + dexmedetomidine group, the analgesic effects of drugs; applied to other groups were observed.The accompanying application of dexmedetomidine and yohimbine abolished its analgesiceffect of dexmedetomidine, however, there were no statistical difference when compared togroups which dexmedetomidine is applied with flumazenil and naloxone. Conclusion: We could not find any effect of flumazenil and naloxane on antinociceptive effect of dexmedetomidine.