Wilson’s Disease: Brain MR Imaging and Proton-MR Spectroscopy Findings

Wilson’s disease is a rarely seen, autosomal recessive disorder which leads to degenerative changes in the liver and brain due to cupper accumulation in them. A Wilson syndrome case who was diagnosed 5 years previously with classic symmetric basal ganglia and thalamus involvement in brain MR imaging and increased glutamate-glycine peaks, decreased N-Acetyl Aspartate(NAA)/Creatin(Cre, increased Myoinositol(Mi)/Cre ratios in Multivoxel proton MR spectroscopy with short and long time to echo(TE) values, was presented here. Spectroscopic findings observed at basal ganglia and both thalami in Wilson’s disease might be due to the neuronal tissue loss and anaerobic glycolysis.