Author/Authors :
Tsompos, Constantinos mesologi county hospital - department of obstetrics and gynecology, Greece , Panoulis, Constantinos athens university - aretaieion hospital - department of obstetrics and gynecology, Greece , Tutouzas, Konstantinos athens university - ippokrateion general hospital - department of surgery, Greece , Zografos, George athens university - ippokrateion general hospital - department of surgery, Greece , Papalois, Apostolos exprerimental research center,elpen pharmaceuticals s.a. inc., Greece
Abstract :
Objective: This experimental study examines the effect of the antioxidant drug “U-74389G” on rat model,particularly in an ischemia–reperfusion (IR) protocol. The effects of this molecule were biochemically studied using mean creatinine phosphokinase (CPK) levels in blood. Materials and Methods: Forty rats with a mean weight of 231.875 g were used in the study. CPK levels were measured at 60 min (groups A and C) and at 120 min of reperfusion (groups B and D); A and B were groups without U-74389G administration,but C and D were groups with U-74389G administration. Results: U-74389G administration significantly increased CPK levels by 35.34%+17.20% (p=0.0260). Reperfusion time non-significantly increased CPK levels by 13.17%+18.05% (p=0.4134). However,U-74389G admi nistration and reperfusion timetogether non-significantly increased CPK levels by 18.52%+9.44% (p=0.0770). Conclusion: U-74389G administration significantly increased CPK levels for a short term; however,these levels could not be restored,and the restoration capacity increases along with reperfusion time.
Keywords :
Creatinine phosphokinase , Ischemia , Reperfusion , U , 74389G
