Author/Authors :
Somdaş, Mehmet Akif Erciyes University - School of Medicine - Department of Otorhinolaryngology, Turkey , Güntürk, İnayet Erciyes University - School of Medicine - Department of Medical Biochemistry, Turkey , Avcı, Deniz Patnos State Hospital - Department of Otorhinolaryngology, Turkey , Yazıcı, Cevat Erciyes University - School of Medicine - Department of Medical Biochemistry, Turkey , Balcıoğlu, Esra Erciyes University - School of Medicine - Department of Histology and Embryology, Turkey , Ünsal, Selim Turgut Özal University - Department of Odiology, Turkey , Gündüz, Mehmet Turgut Özal University - School of Medicine - Department of Otorhinolaryngology, Turkey
Abstract :
Objective: To investigate the changes in otoacoustic emissions (OAEs) for detecting the ototoxicity of cisplatin and to study the possible preventive effect of N-acetylcysteine (NAC) in cisplatin ototoxicity.Materials and Methods: This study was conducted on 21 Wistar albino rats in four groups. Cisplatin, cisplatin plus NAC,NAC alone, and saline were intraperitoneally administered. The rats were anesthetized to study the otoacoustic emissions before and after the experiment.Results: The OAEs were attenuated in the cisplatin group: (−1.31/−4.90), (6.28/4.58), (4.00/0.93), (2.73/−3.74),(2.66/−4.53).The group that received NAC in addition to cisplatin had better OAEs.Conclusion: Cisplatin ototoxicity can be detected by OAE testing in rats, and NAC may reduce the ototoxic effect.
Keywords :
Ototoxicity , cisplatin , NAC , N , acetylcysteine , hearing
