Author/Authors :
Danish, Lubna Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (CIRBS) - International Islamic University Islamabad (IIUI) - Islamabad, Pakistan , Siddiq, Riffat Department of Maxillofacial Surgery - Rehman College of Dentistry - Peshawar, Pakistan , Jahan, Sarwat Northwest School of Medicine - Phase-V Hayatabad - Peshawar, Pakistan , Taneez, Mehwish Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (CIRBS) - International Islamic University Islamabad (IIUI) - Islamabad, Pakistan , Khan, Manzoor Department of Medicine - Khyber Teaching Hospital - Peshawar, Pakistan , Sandhu, Marva Department of Pharmacology - National Institute of Health (NIH) - Islamabad, Pakistan
Abstract :
Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the
cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil
can act as a hepatoprotective by maintaining calcium homeostasis. the present study was conducted to study the hepatoprotective
activity of Cimetidine and Verapamil against the toxicity induced by paracetamol. In addition to the group receiving only distilled
water or 300mg/kg paracetamol additional groups were added treated with 150mg/kg Cimetidine and Verapamil alone or both.
Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters
were observed in the groups receiving Cimetidine and Verapamil. Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity.
Keywords :
Comparative Study , Protective Effect , Cimetidine , Verapamil , Paracetamol-Induced Hepatotoxicity , Mice
