Title of article :
PREPARATION METHOD AND CHARACTERIZATION OF INCLUSION COMPLEX OF THEOPHYLLINE/BETA
Author/Authors :
Mokhtar, Marina Universiti Sains Malaysia - School of Chemical Sciences, Malaysia , Mokhtar, Marina Universiti Teknologi MARA - Department of Applied Sciences, Malaysia , Adnan, Rohana Universiti Sains Malaysia - School of Chemical Sciences, Malaysia
Abstract :
Theophylline is a therapy for respiratory diseases which has limited use due to its rapid absorption and becomes inactive metabolite as methyluric acid when administered in the body system. These limitations can be reduced by complexation with inclusion of the beta cyclodextrin. The complex was prepared by kneading, slow evaporation and freeze drying methods. The structure of the complex was determined by FT-IR, DSC and 1H NMR. The molecular modeling study indicated theophylline lies exactly in the cavity of β-CD with hydrogen bonding.
Keywords :
theophylline , inclusion complex , beta cyclodextrin , host , guest system
Journal title :
Esteem Academic Journal
Journal title :
Esteem Academic Journal
