Stimulating Cellular and Humoral Natural Resistance Factors in Calves with Bronchopneumonia Using Glycyrrhizic Acid

This paper studied the effect of glycyrrhizic acid on the growth and development of calves with an acute form of bronchopneumonia. The research was performed at the Department of Morphology, Pathology, Pharmacy, and Non-Communicable Diseases of the Federal State Budgetary Educational Institution of Higher Vocational Education “Bashkir State Agrarian University.” The research’s scientific and practical parts were carried out in the environment of the State Unitary Agricultural Enterprise “Alekseevsky” Collective Farm in the Republic of Bashkortostan. When conducting research, clinical, biochemical, and immunological research methods were used. A beneficial effect of glycyrrhizic acid on the body of sick animals was observed during research. It was reflected in their growth and development, the animals’ improved clinical and physiological parameters. It was also noted that the calf growth and development rate depended on the dose of glycyrrhizic acid. Glycyrrhizic acid was given to animals in the form of aqueous solutions. When applying it at a dose of 50 mg/kg, a high efficiency in calves growth was obtained. The data obtained on the serotonin and histamine contents indicate that the calf body responded with a set of adaptive reactions. Therefore, glycyrrhizic acid activates biochemical and immunological processes aimed at coordinating the use of energy resources, which are a presage of a favorable outcome of the disease due to increased metabolism and have a positive effect on the calf growth and development.