Leukocyte and Platelet Rich Fibrin: Characteristics and Clinical Applications in Dentistry

Several platelet concentrates are avaliable in different techniques; however, their biological contents vary from one to another. Leukocyte platelet-rich fibrin (L-PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. Although plateletderived growth factors play an important role in biology of PRF, fibrin organization and the leukocyte content are other two key variables. Due to the growth factor and cell content, L-PRF has a positive effect on natural wound healing. Frequency of L-PRF usage in dentistry is increasing, because of its positive effects on soft tissue and bone healing.