Title of article :
Alkaline phosphatase levels of murine pre-osteoblastic cells on anodized and annealed titanium surfaces
Author/Authors :
yeniyol, sinem istanbul university - faculty of dentistry - department of oral implantology, İstanbul, Turkey , ricci, john lawrence new york university college of dentistry - department of biomaterials and biomimetics, New York, USA
Abstract :
Purpose This study aimed to evaluate the initial adhesion morphology and alkaline phosphatase (ALP) activity of murine pre-osteoblastic MC3T3-E1 cells cultured on anatase/rutile mixed-phase TiO_2 thin films with photocatalytical activity with previously confirmed antibacterial properties. Materials and methods Anatase/rutile mixed-phase TiO_2 thin films fabricated by anodization and annealing of cpTi were used to culture MC3T3-E1 cells to evaluate the initial cellular adhesion morphology and ALP activity in vitro. Results Compared with MC3T3-E1 cells cultured on cpTi substrates and the control group, cells cultured on anatase/rutile mixed-phase Ti_O2 thin films exhibited similar ALP levels after cell culture day 9. Conclusion Anodizing and annealing processes fabricate multifunctional surfaces on cpTi with improved osteogenic properties for implants.
Keywords :
Titanium dioxide , surface roughness , crystal phase , alkaline phosphatase , pre , osteoblastic cell
Journal title :
European Oral Research
Journal title :
European Oral Research
