Author/Authors :
Mohideen, Mazlin Faculty of Pharmacy and Health Sciences - Universiti Kuala Lumpur - Royal College of Medicine Perak (UniKL-RCMP) - 30450 Ipoh - Perak, Malaysia - Centre for Drug Research - Universiti Sains Malaysia (USM) - 11800 Minden - Pulau Pinang, Malaysia , Kamaruzaman, Nur Azzalia National Poison Centre - Universiti Sains Malaysia (USM) - 11800 Minden - Pulau Pinang, Malaysia , Mordi, Mohd Nizam Centre for Drug Research - Universiti Sains Malaysia (USM) - 11800 Minden - Pulau Pinang, Malaysia , Mahsufi Mansor, Sharif Centre for Drug Research - Universiti Sains Malaysia (USM) - 11800 Minden - Pulau Pinang, Malaysia
Abstract :
A simple and efficient synthetic methodology has been developed via Krapcho decarboxylation to construct four new N2,N9-benzylated quaternary β-carbolin-3-ium bromide salts (5a-d) by treating ethyl-β-carboline-3-carboxylate (4) with various substituted benzyl bromides in the presence of NaH in DMF under refluxing conditions with very good to excellent yields (81-95%).
Keywords :
β-carboline , N2,N9-benzylatedquaternary β-carbolin-3-ium bromide , ethyl-β-carboline 3-carboxylate , Krapcho decarboxylation
