Oxidative Stress and The Activities of Catalase , GST in Thalassemic Patients

The study concentrated on measuring the lipid peroxidation marker malon di aldehyde (MDA) in sera of thirty five patients with minor Thalassemia (Tm), thirty five with major Thalassemia (I M) and thirty five healthy control, their age ranged from (17-30) years. Erythrocytes enzymes (Glutathione S - transferase (GS I )and Catalase) were assayed . The results showed a significant elevation in (MDA) in sera of both patient groups compared to control. An increase in the activity of catalase and GST in erythrocytes of minor Thalassemic patients compared to control was found to be significant. Also, a high significant increase in the activity of GST for major Thalassemic patients compared to minor lhalassemic patients and control was found. On the other hand, the catalase activity for major l halassemic patients was found in compatible with that of the control group.