Title of article :
Evaluation of α1-Antitrypsine and Reduced Glutathione in Iraqi Patients of Diabetes Mellitus Type II.
Author/Authors :
Al-Tai, A. F. University of AL-Nahrain - College of Medicine AL-Nahrain, Iraq , Farid, Y. Y. Z. University of Baghdad - College of Education Ibn AL-Haitham - Department of Chemistry, Iraq , AL- Tai, W.F. University of Baghdad - College of Education Ibn AL-Haitham - Department of Chemistry, Iraq
Abstract :
In order to investigate the levels of reduced glutathione GSH and α1-antitrypsine in the sera of 20 type 2 diabetic patients and 10 healthy subjects, were enrolled in this study. A significant reduction in GSH level was found in the patient group compared with control. On the other hand a significant elevation in α1-antitrypsine in patient compared with control was observed. Correlation between α1-antitrypsine and reduced glutathion was found to be positive(+Ve) for diabetes mellitus type2 patients and negative (-Ve) for healthy control with r values0.257 and – 0.339 resp ectively. In conclusion the depletion of GSH as antioxidant defense insured higher free radical generation in diabetic patients which is conformed by the high α1-antitrypsine level in the sera
Keywords :
α1 , Antitrypsine , Glutathione , Diabetes Mellitus Type 2
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
