Inhibitory Effect of Synthesized Acridone Derivatives Containing 1, 3, 4 –Thiadiazole on Cholesterol Enzymatic Activity

Synthesis of Diphenylamine-2, 4`-dicarboxylic acid {1}, 9(10H)-Acridone-2-carboxylic acid {2}, 2-[5-amino-1, 3, 4-thiadiazole-2-yl]-9(10H)-acridone {3}. Synthesized compounds were identified using sp ectral (FTIR, UV) .The results were discussed and found in agreement with the suggested structures. Ten samples were collected from normal and patients with atherosclerosis and then addition of 50μl of 2-[5-amino-1, 3, 4-thiadiazole-2-yl]-9(10H)-acridone to serum of patients with atherosclerosis in Al-Kadimia teaching hosp ital, diagnosis was established depending on clinical technique. The study showed inhibition effect of the synthesized compounds on cholesterol level of patients using addition of 50μl of 2-[5-amino-1, 3, 4-thiadiazole-2-yl]-9(10H)-acridone to patients that means the above compound work as inhibitor of cholesterol level.