Author/Authors :
Ali, Kh. F. University of Baghdad - College of Education Ibn Al- Haitham - Department of Chemistry, Iraq , Hussein, Dh. F University of Baghdad - College of Education Ibn Al- Haitham - Department of Chemistry, Iraq , Tomma, J. H. University of Baghdad - College of Education Ibn Al- Haitham - Department of Chemistry, Iraq
Abstract :
This work involves synthesis of amides containing isoxazoline unit starting with chalcone; 4-[3-(3‾- nitrophenyl)-2-propene- 1-one]-aniline[I]. 4-Aminoacetophenone was reacted with 3- nitrobenzaldehyde in basic medium giving chalcone [I] by claisen-schemidt reaction. The chalcone [I] was reacted with hydroxylamine hydrochloride giving isoxazoline [II] in NaOH basic medium. The amides with structural formula [III]a-h were prepared by the reaction of amino compounds ; isoxazoline [II] with different acid chlorides in dry pyridine and using DMF as a solvent at 4^0C. All the synthesized compounds have been characterized by melting points , FTIR and 1HMNR (of compound [III]a) spectroscopy.
